AN ASSESSMENT HEMATOLOGICAL PROFILE AND LIVER FUNCTION TEST OF CHILDREN WITH HEPATITIS TYPHOID FEVER AT Al-Batool Hospital-Diyala-Iraq

Abstract

Introduction: Typhoid is one of the diseases caused by Salmonella Typhi, An estimated 200,000 people die annually out of approximately 21.6 million people who are sick with typhoid fever. Typhoid liver injury is in the form of biochemical changes although there is little evidence of liver injury due to septicemia or salmonella attack. May cause significant liver damage with few characteristic clinical signs or abnormal tests for an accompanying disease. Aim of study to: To know the characteristics and functions of blood and liver associated with typhoid fever in children diagnosed by biochemical test. Methods: 30 cases of typhoid fever , aged between (1 to 6) years, were received at Al-Batool Hospital in Diyala Governorate - Iraq. Comparing it with 30 healthy children after a clinical diagnosis was made, this was confirmed by the Widdall test,which was performed to assess liver function in sick children and hematological variables. They were diagnosed with typhoid fever recorded in hospital medical records for the period from March 2021 to August 2021. Results: The sample consisted of 30 patients, 10 boys and 20 girls. Most patients are found between 6 and 1 years of age. Blood analysis showed that 48.51% of patients had iron deficiency anemia. RBC levels in 85.22% of patients were normal. Low MCV, low MCH, was found in 47.56%, 37.22% of patients. Leukopenia was present in 17.23% of the children. All patients had normal basal values. Leukopenia, stripe neutropenia, segmented neutropenia, lymphocytosis, and leukocytosis have been found in pediatric patients. S.A.S.T was raised in 17 [50%] cases and S.A.L.T was raised in 23 [46%] cases out of a total of 30 cases. Most of the cases presented with elevated S.A.S.T and S.A.L.T in the second week of fever. Conclusion: As a result of these complications, subcutaneous hematoma, subcutaneous abscess, cutaneous ulcers, and biochemical parameters can be able to tolerate association and thus serve as indications for more reliable and diagnostic assistance for infection that could alter the necessary antibiotic therapy