PLASMA LEVELS OF MDA AND LIPID PROFILE IN PATIENTS WITH HYPERTHYROIDISM
Keywords:
Grave’s disease, MDA, lipid peroxidation, hyperthyroidismAbstract
Hyperthyroidism is an endocrine condition of the thyroid gland characterized by low TSH levels and high thyroxine (T4) and triiodothyronine (T3) hormone levels. Our goal was to determine the oxidative status in hyperthyroidism patients by measuring malondialdehyde (MDA) and find out its correlation with the thyroid function hormones and lipid profile in the plasma. Sixty patients with overt hyperthyroidism were included in the study with 30 heathy people with normal thyroid function. The thyroid hormone profile has shown that hyperthyroidism patients have significant (P<0.05) low levels of TSH (0.53±0.11 mIU/mL), but significant (P><0.05) high levels of T3 (6.40±0.91 nmol/L) and T4 (175.36±21.27 nmol/L) in their plasma, compared to normal thyroid people. Hyperthyroidism patients have shown non-significant (P>0.05) alterations in the plasma triglycerides (104.08±17.13 mg/dL), and cholesterol (149.89±12.07 mg/dL), compared to the plasma of normal control. But, they have shown significant (P
<0.05) lower levels of HDL (42.39±6.81 mg/dL) compared to the control. Furthermore, hyperthyroidism patients have shown significant (P><0.05) higher levels of MDA (1.63±0.60 µmol/L) in their plasma compared to the plasma of normal thyroid function people (0.54±0.13 µmol/L). The high levels of MDA in hyperthyroidism patients suggested lipid peroxidation, which occurs from an imbalance between oxidants and antioxidants not just in the thyroid gland but also systemically, as assessed in the plasma.>
References
Tunbridge, W., et al., The spectrum of thyroid disease in a community: the Whickham survey. Clinical endocrinology, 1977. 7(6): p. 481-493.
Reid, J.R. and S.F. Wheeler, Hyperthyroidism: diagnosis and treatment. American family physician, 2005. 72(4): p. 623-630.
Association, A.T., et al., Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid, 2011. 21(6): p. 593-646.
Vanderpump, M.P., The epidemiology of thyroid disease. British medical bulletin, 2011. 99(1).
Ahmed H, Hussein SN, Ali RA, Almashhadani HA, Ayvaz A. Environmental effects on intestinal parasitic disease transmission in Mosul governorate. Journal of Pharmaceutical Negative Results¦ Volume. 2022;13(3):269.
Gozu, H.I., et al., Genetics and phenomics of inherited and sporadic non-autoimmune hyperthyroidism. Molecular and cellular endocrinology, 2010. 322(1-2): p. 125-134.
Schwartz, F., et al., Incidence rate of symptomatic painless thyroiditis presenting with thyrotoxicosis in Denmark as evaluated by consecutive thyroid scintigraphies. Scandinavian journal of clinical and laboratory investigation, 2013. 73(3): p. 240-244.
Kravets, I., Hyperthyroidism: diagnosis and treatment. American family physician, 2016. 93(5): p. 363-370.
Taylor, P.N., et al., Global epidemiology of hyperthyroidism and hypothyroidism. Nature Reviews Endocrinology, 2018. 14(5): p. 301-316.
Taay, Y.M. and M.T. Mohammed, Evaluation of serum reactive oxygen species and glutathione peroxidase in iraqi obese/obese-hypertension females. Plant Archives, 2020. 20(2): p. 1165-1168.
Kadhim, S.M., et al., Oxidative Stress in Multiple Sclerosis Disease. Diyala Journal of Medicine, 2021. 21(2): p. 33-40.
Ahmed GS, Shari FH, Alwan HA, Obaid RF, Almashhadani HA, Kadhim MM. The Level of Nitric Oxide Synthase and Nitric Oxide in Hypertensive Women. Journal of Pharmaceutical Negative Results¦ Volume. 2022;13(3):237.
Mohammed, M.T., et al., Free radicals and human health. International Journal of Innovation Sciences and Research, 2015. 4(6): p. 218-223.
Su, L.-J., et al., Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis. Oxidative medicine and cellular longevity, 2019. 2019.
Barrera, G., et al., Lipid peroxidation-derived aldehydes, 4-hydroxynonenal and malondialdehyde in aging-related disorders. Antioxidants, 2018. 7(8): p. 102.
Costilla, M., et al., Oxidative stress produced by hyperthyroidism status induces the antioxidant enzyme transcription through the activation of the Nrf-2 factor in lymphoid tissues of Balb/c mice. Oxidative medicine and cellular longevity, 2019. 2019.
Golbidi, S. and I. Laher, Antioxidant therapy in human endocrine disorders. Med Sci Monit, 2010. 16(1): p. 9-24.
Benge, J. and S. Aust, Estimation of serum Malondialdehyde level in hoffee PA. and Jones ME. Methods in Enzymology Hoffee Jones. Academic Press, New York, San Francisco, London, ASubsidinary of Harcoart Brace Jovanovich, Publisher, 1978. 51: p. 302.
Hameed RY, Nathir I, Abdulsahib WK, Almashhadani HA. Study the effect of biosynthesized gold nanoparticles on the enzymatic activity of alpha-Amylase. Research Journal of Pharmacy and Technology. 2022 Aug 1;15(8):3459-65.
Erem, C., et al., Ischemia-modified albümin and malondialdehyde levels in patients with overt and subclinical hyperthyroidism: effects of treatment on oxidative stress. Endocrine journal, 2015: p. EJ14-0542.
Cetinkaya, A., et al., Levels of Malondialdehyde and Superoxide Dismutase in Subclinical Hyperthyroidism. Mediators of Inflammation, 2005. 2005: p. 176923.
Lassoued, S., et al., A Comparative Study of the Oxidative Profile in Graves’ Disease, Hashimoto’s Thyroiditis, and Papillary Thyroid Cancer. Biological Trace Element Research, 2010. 138(1): p. 107-115.
Mohammed AK, Al-Shaheeb S, Fawzi OF, Almashhadani HA, Kadhim MM. Evaluation of Interlukein-6 and Vitamin D in Patients with COVID-19. Research Journal of Biotechnology Vol. 2022 Oct;17(10).
Rizos, C., M. Elisaf, and E. Liberopoulos, Effects of thyroid dysfunction on lipid profile. The open cardiovascular medicine journal, 2011. 5: p. 76.
Altaher, W.H., E.M. Ahemd, and A. Ismail, Assessment of lipids profile in hyperthyroidism Sudanese patients in North Kordofan State, Sudan. 2013.
Dhannoon, A.Y. and A.A.A. Al-Hadidy, Estimation of Visfatin, Adiponectin Hormone and Lipid Profile in Hyperthyroidism Patients. Annals of the Romanian Society for Cell Biology, 2021: p. 5617-5626.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
