STUDY OF THE EFFECT OF SOME ALKALOIDS ON THE CONTRACTILE ACTIVITY OF AORTIC SMOOTH MUSCLE CELLS

Authors

  • Mirzayeva Yulduzkhon Takhirjonovna Alfraganus University, Tashkent, Uzbekistan, Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, Uzbekistan

Keywords:

smooth muscle, sarcoplasmic reticulum, aorta, phenylephrine

Abstract

The aim of the work was to study the effect of 1-O-acetylkarakoline, a derivative of the diterpenoid alkaloid karakolin, isolated from the plant Aconitum karakolicum, on the contractile activity of smooth muscle cells (SMC) of the rat aorta. Karakolin has a pronounced antiarrhythmic effect, which is determined by the presence of specific functionally important groups in its structure [3]. Thus, the replacement of the OH-group at the carbon atom C-1 of the lycoketonin skeleton of Karakolin with an acetyl group (Fig. 1) leads to a significant increase in antiarrhythmic activity of 1-O-acetylkarakoline

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Published

2024-10-24

How to Cite

Mirzayeva Yulduzkhon Takhirjonovna. (2024). STUDY OF THE EFFECT OF SOME ALKALOIDS ON THE CONTRACTILE ACTIVITY OF AORTIC SMOOTH MUSCLE CELLS. World Bulletin of Public Health, 39, 93-97. Retrieved from https://scholarexpress.net/index.php/wbph/article/view/4669

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