STUDY OF COLLAGEN IV INDICATORS IN URINE BEFORE AND AFTER TREATMENTS IN PATIENTS WITH HEPATORENAL SYNDROME WITH LIVER CIRRHOSIS OF VIRUS ETIOLOGY (HEPATITIS B AND C)
Keywords:
hepatitis B, hepatitis C, liver cirrhosis, hepatorenal syndromeAbstract
Cirrhosis of the liver is manifested by necrosis of hepatocytes, disruption of its normal architecture due to diffuse growth of connective tissue and the formation of regeneration nodules, as well as progressive fibrosis. The article presents a modern approach to the treatment of hepatorenal syndrome, one of the severe complications of the disease. The effect of eplerenone, Lornithine L-aspartate and glutathione drugs on kidney fibrosis was evaluated based on complex treatment
References
Bogomolov P.O., Matsievich M.V., Bueverov A.O., Kokina K.Yu., Voronkova N.V., Beznosenko V.D. Cirrhosis cake in Moskovskoy oblast: tsifry and facty // Almanakh klinicheskoy meditsiny. 2018. No. 1. 59-67-s.
Gadaev AG, Abdulazizkhodjiev B, Jo'raeva MA, Advanced hepatorenal syndrome in viral and alcoholic liver cirrhosis. Therapeutic Journal of Uzbekistan. 2021, No. 2 204-209-S.
Ivashkin V.T., Maevskaya M.V., Pavlov Ch.S., Fedosina E.A., Bessonova E.N., Pirogova I.Yu., Garbuzenko D.V. Klinicheskie rekomendatsii Rossiyskogo obshchestva po izucheniyu pecheni i Rossiyskoi gastroenterologisticheskoy assotsiatsii po lecheniyu oslojneniy cirrhosis pecheni. Rossiyskiy journal of gastroenterology, hepatology, coloproctology. 2016;26(4):71-102.
Kalinin A.V., Khazanov A.I., Gastroenterology and hepatology: diagnostics and lechenie.-Moscow: Miklash 2006.
Amin AA, Alabsawy EI, Jalan R, Davenport A: Epidemiology, pathophysiology, and management of hepatorenal syndrome. Semin Nephrol. 2019, 39:17-30.10.1016/j.semnephrol.2018.10.002.
Angeli P, Gines P, Wong F, Bernardi M, Boyer TD, Gerbes A, et al. Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites. Gut 2015;64(4):531–7.
Basnayake SK, Easterbrook PJ. Wide variation in estimates of global prevalence and burden of chronic hepatitis B and C infection cited in published literature. J Viral Hepat. 2016;23(7): 545–59. doi: 10.1111/jvh.12519. 2. GBD 2013.
Fida S, Khurshid SMS, Mansoor H. Frequency of Hepatorenal Syndrome Among Patients With Cirrhosis and Outcome After Treatment. Cureus. 2020 Aug 25;12(8):e10016. doi: 10.7759/cureus.10016. PMID: 32983712; PMCID: PMC7515548.
Ginis P, Schrier RW. Renal failure in cirrhosis. N Engl J Med 2009;361(13):1279–90.
Gracia-Sancho J, Marrone G, Fernbéndez-Iglesias A: Hepatic microcirculation and mechanisms of portal hypertension. Nat Rev Gastroenterol Hepatol. 2019, 16:221-234. 10.1038/s41575- 018-0097-3.
Habas E, Ibrahim AR, Moursi MO, Shraim BA, Elgamal ME, Elzouki AN. Update on hepatorenal syndrome: Definition, Pathogenesis, and management. Arab J Gastroenterol. 2022 May;23(2):125-133. doi: 10.1016/j.ajg.2022.01.005. Epub 2022 Apr 23. PMID: 35473682.
Lehmann J, Praktiknjo M, Nielsen MJ, Schierwagen R, Meyer C, Thomas D, Violi F, Strassburg CP, Bendtsen F, Møller S, Krag A, Karsdal MA, Leeming DJ, Trebicka J. Collagen type IV remodeling gender- specifically predicts mortality in decompensated cirrhosis. Liver Int. 2019 May;39(5):885-893. doi: 10.1111/liv.14070. Epub 2019 Mar 7. PMID: 30739387; PMCID: PMC6594031.
Majid B, Khan R, Junaid Z, et al.: Assessment of knowledge about the risk factors of chronic liver disease in patients admitted to Civil Hospital Karachi. Cureus. 2019, 11:5945. 10.7759/cureus.5945.
Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;385(9963):117–71. doi: 10.1016/S0140-6736(14)61682-2.
Planas R, Montoliu S, Ballesty B, Rivera M, Miquel M, Masnou H, et al. Natural history of patients hospitalized for management of cirrhotic ascites. Clin Gastroenterol Hepatol 2006;4(11):1385–1394.e1.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
