MASS SPECTROMETRIC IDENTIFICATION OF BLOODSTREAM INFECTION AGENTS: EXPERIENCE IN PEDIATRIC PRACTICE
Keywords:
bloodstream infections, bacteria, microscopic fungiAbstract
Rapid diagnostics of bloodstream infections is a pressing issue in modern pediatrics. The paper presents data from a comparative analysis of two methods for identifying microorganisms in the blood of children with suspected bloodstream infections: routine microbiological testing and MAldITOF mass spectrometry. The results obtained using the mass spectrometric (MAldI-TOF) method for identifying microorganisms in blood cultures from children with bloodstream infections containing one pathogen are highly consistent with the results of classical microbiological testing (Cohen's kappa 0.97, p < 0.001). MAldI-TOF mass spectrometric identification of bloodstream infection pathogens can be recommended as an additional diagnostic method aimed at reducing analysis time.
References
Baranov A.A., Namazova-Baranova L.S.,
Ilyin A.G., Bulgakov V.A., Antonova E.V.,
Smirnov I.E. Scientific research in
pediatrics: directions, achievements, prospects. Russian pediatric journal. 2013;
: 4–14.
Chebotkevich V.N., Kaitanjan E.I., Burylev
V.V., Shchetinkina E.E. Modern methods of
laboratory diagnostics of sepsis. Clinical
microbiology and antimicrobial
chemotherapy. 2013; 15 (4): 295–300. 3.
Lominadze G.G., Semenova E.A.,
Motuzova O.V., Kalakutskaya A.N.,
Balabanov A.S., Lazareva A.V., et al.
Application of MALDI-TOF mass
spectrometry for identification of
microorganisms in blood cultures of
patients with suspected sepsis. Diagnostic
issues in pediatrics. 2013; 5 (2): 28–32.
Mayansky N.A., Kalakutskaya A.N.,
Motuzova O.V., Lominadze G.G.,
Kryzhanovskaya O.A., Katosova L.K.
MALDI-TOF mass spectrometry in routine
work of microbiological laboratory.
Diagnostic issues in pediatrics. 2011: 3
(5): 20–5
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