THE IMPACT OF THE AZF GENE DEFECT ON SPERMATOGENESIS PARAMETERS IN INFERTILITY MEN

Abstract

This study investigates the impact of AZF gene defects on spermatogenesis parameters in men with fertility disorders. A comparative analysis was conducted between two groups of men: AZF– (n = 150) and AZF+ (n = 69). The results revealed that the presence of AZF gene defects significantly impaired spermatogenesis parameters such as sperm concentration, motility, viability, and morphology. In the AZF+ group, a high frequency of azoospermia (79.7%) was observed, with significantly lower sperm viability. Our findings emphasize the importance of genetic testing for diagnosing male infertility and highlight the need for considering AZF gene defects when developing treatment methods